Cat.No.:BI-20413
应用领域：
1）骨代谢疾病
2）Wnt信号通路
试剂盒特点：
检测方法：夹心ELISA，HRP/TMB显色
样本类型：血清
样品量：20ul/test
标准品范围：0-160 pmol/L
检测灵敏度：1.7pmol/L
孵育条件：2h/1h/30min

检测特点

BI-20413

BI-20412

孵育时间

2h/1h/30min

overnight

样品处理

直接测定

需要1:4稀释

标准品范围

0-160pmol/L

0-50pmol/L

1

Comparative Effect of Zoledronic Acid Versus Denosumab on Serum Sclerostin

and Dickkopf-1 Levels of Naive Postmenopausal Women With Low Bone Mass: A

Randomized, Head-to-Head Clinical Trial. Athanasios D. Anastasilakis, et al.

J. Clin. Endocrinol. Metab., Aug 2013; 98: 3206 - 3212.

2

Elevated Serum Dickopff-1 Levels Increase Risk of Hip and Vertebral Fracture in Older Caucasian Women. Aarthi Arasu,et al. Endocr. Rev., Jun 2013; 34: SAT-224.

3

Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis. Diederik P C de Rooy,et al. Ann Rheum Dis, May 2013; 72: 769 - 775.

4

High dickkopf-1 levels in sera and leukocytes from children with 21-

hydroxylase deficiency on chronic glucocorticoid treatment. Giacomina Brunetti,et al. Am J Physiol Endocrinol Metab, Mar 2013; 304: E546 - E554.

5

Sclerostin and DKK1 in postmenopausal osteoporosis treated with denosumab. D Gatti,et al. J Bone Miner Res, Nov 2012; 27(11): 2259-63. 

6

Sclerostin Levels Associated with Inhibition of the Wnt/β-Catenin Signaling and Reduced Bone Turnover in Type 2 Diabetes Mellitus. Agostino Gaudio,et al. J. Clin. Endocrinol. Metab., Oct 2012; 97: 3744 - 3750.

7

Serum Osteoprotegerin, RANKL, and Dkk-1 Levels in Adults with Langerhans

Cell Histiocytosis. Polyzois Makras,et al. J. Clin. Endocrinol. Metab., Apr 2012; 97: E618 - E621

8

High level of functional dickkopf-1 predicts protection from syndesmophyte

formation in patients with ankylosing spondylitis. Gisela Ruiz Heiland,et al. Ann Rheum Dis, Apr 2012; 71: 572 - 574. 

9

Assessment of circulating Dickkopf-1 with a new two-site immunoassay in

healthy subjects and women with breast cancer and bone metastases. N Voorzanger-Rousselot, et al. Calcif Tissue Int, May 1, 2009; 84(5): 348-354

10

Circulating Dickkopf-1 and Radiological Progression in Patients with Early

Rheumatoid Arthritis Treated with Etanercept. Patrick Garnero,et al. J Rheumatol, Oct 2008.

11

Increased Sclerostin Serum Levels Associated with Bone Formation and Resorption Markers in Patients with Immobilization-Induced Bone Loss. Agostino Gaudio,et al. J. Clin. Endocrinol. Metab., May 2010; 95: 2248 - 2253.

12

High Serum Sclerostin Correlates with Advanced Stage, Increased Bone

Resorption, Reduced Osteoblast Function, and Poor Survival in Newly-Diagnosed Patients with Multiple Myeloma. Evangelos Terpos,et al. Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 425.

13

The Effect of Zoledronic Acid on Serum Dickkopf-1, Osteoprotegerin, and RANKL

in Patients with Paget's Disease of Bone. S A Polyzos, et al. Horm Metab Res, Aug 2009 

14

Glucocorticoids Attenuate the Stimulatory Effect on Bone Formation by

Bortezomib. Thomas Lund,et al. Blood (ASH Annual Meeting Abstracts), Nov 2008; 112: 5183.