Monkey Anti Insulin IgG ELISA 猴抗胰岛素IgG检测试剂盒说明书

猴抗胰岛素IgG检测试剂盒

Monkey Anti Insulin IgG ELISA Kit  

cat#3610-MKG

INTENDED USE

ADI’s Anti-Insulin ELISA Test Kit has been designed for the quantitative determination ofAutoantibodies to Human/monkey Insulin in serum and plasma. The assay is useful forthe determination of Type I Diabetes, as well as for screening purposes to detectdeveloping insulin autoantibodies in monkey under insulin therapy.

INTRODUCTION

Type I Diabetes is mainly characterized by limited or fully missing secretion of the hormoneinsulin. Morphological studies demonstrated a destruction of the beta cells of the so-calledLangerhanns's Cells (Islet Cells) in Type I diabetics. Numerous researchers described theappearance of antibodies directed against the islet cells and insulin as the causal reasonfor the onset of the disease. Anti-Insulin antibodies are found in 37 percent of patients withnewly detected Type I Diabetes, in 4% of their relatives of the first degree and in up to1.5% of healthy controls. A positive correlation between the appearance of anti-Insulin andanti-Islet Cell antibodies has been reported. Anti-Insulin autoantibodies may be detectedseveral months and in some cases years before the onset of the fully clinical manifestationof the diseases. Occasionally also autoantibodies to Pro-Insulin may appear. These ''true''anti-Insulin autoantibodies directed against endogenous insulin have to be distinguishedfrom those autoantibodies which are developed in insulin dependent diabetics undergoingtherapy with insulin preparations of animal origin. In fact the latter have to be referred toside effects. These side effects may occur as local reactions of the skin by development ofinsulin-specific autoantibodies. These autoantibodies are causing the formation of aninsulin depot and they may simulate a resistance against the hormonal treatment withanimal insulin.

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